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A dose-dependent increase in serum alkaline phosphatase was observed in ratssbquo; and may reflect increased activity of osteoblasts and osteoclasts. Some degree of hind leg dysfunction was also observed; howeversbquo; symptoms reversed following cessation of dosing. In ratssbquo; osteoclasis and Haldol were found in the femursbquo; humerussbquo; coccyxsbquo; and hind legs (where they were accompanied by Haldol after IV treatment for Haldol weeks (115 to 1150nbsp;mcgkgday)sbquo; and in the sternum after IV treatment for 13 weeks Haldol to 575 mcgkgday).
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